diff --git a/Lib/uuid.py b/Lib/uuid.py
index a6643ed4515..5b24e2c29ec 100644
--- a/Lib/uuid.py
+++ b/Lib/uuid.py
@@ -44,6 +44,8 @@ Typical usage:
     UUID('00010203-0405-0607-0809-0a0b0c0d0e0f')
 """
 
+import os
+
 __author__ = 'Ka-Ping Yee <ping@zesty.ca>'
 
 RESERVED_NCS, RFC_4122, RESERVED_MICROSOFT, RESERVED_FUTURE = [
@@ -456,7 +458,7 @@ def _netbios_getnode():
 
 # If ctypes is available, use it to find system routines for UUID generation.
 # XXX This makes the module non-thread-safe!
-_uuid_generate_random = _uuid_generate_time = _UuidCreate = None
+_uuid_generate_time = _UuidCreate = None
 try:
     import ctypes, ctypes.util
     import sys
@@ -471,12 +473,9 @@ try:
             lib = ctypes.CDLL(ctypes.util.find_library(libname))
         except Exception:
             continue
-        if hasattr(lib, 'uuid_generate_random'):
-            _uuid_generate_random = lib.uuid_generate_random
         if hasattr(lib, 'uuid_generate_time'):
             _uuid_generate_time = lib.uuid_generate_time
-            if _uuid_generate_random is not None:
-                break  # found everything we were looking for
+            break
     del _libnames
 
     # The uuid_generate_* functions are broken on MacOS X 10.5, as noted
@@ -489,7 +488,7 @@ try:
     if sys.platform == 'darwin':
         import os
         if int(os.uname().release.split('.')[0]) >= 9:
-            _uuid_generate_random = _uuid_generate_time = None
+            _uuid_generate_time = None
 
     # On Windows prior to 2000, UuidCreate gives a UUID containing the
     # hardware address.  On Windows 2000 and later, UuidCreate makes a
@@ -600,20 +599,7 @@ def uuid3(namespace, name):
 
 def uuid4():
     """Generate a random UUID."""
-
-    # When the system provides a version-4 UUID generator, use it.
-    if _uuid_generate_random:
-        _buffer = ctypes.create_string_buffer(16)
-        _uuid_generate_random(_buffer)
-        return UUID(bytes=bytes_(_buffer.raw))
-
-    # Otherwise, get randomness from urandom or the 'random' module.
-    try:
-        import os
-        return UUID(bytes=os.urandom(16), version=4)
-    except Exception:
-        import random
-        return UUID(int=random.getrandbits(128), version=4)
+    return UUID(bytes=os.urandom(16), version=4)
 
 def uuid5(namespace, name):
     """Generate a UUID from the SHA-1 hash of a namespace UUID and a name."""
diff --git a/Misc/NEWS b/Misc/NEWS
index be859edcdcc..6a9afeb1e10 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -48,6 +48,8 @@ Library
 - Issue #25503: Fixed inspect.getdoc() for inherited docstrings of properties.
   Original patch by John Mark Vandenberg.
 
+- Issue #25515: Always use os.urandom as a source of randomness in uuid.uuid4.
+
 - Issue #21827: Fixed textwrap.dedent() for the case when largest common
   whitespace is a substring of smallest leading whitespace.
   Based on patch by Robert Li.