diff --git a/Modules/_ssl.c b/Modules/_ssl.c
index 213c7d21510..832b5f96bff 100644
--- a/Modules/_ssl.c
+++ b/Modules/_ssl.c
@@ -280,7 +280,7 @@ static unsigned int _ssl_locks_count = 0;
 typedef struct {
     PyObject_HEAD
     SSL_CTX *ctx;
-#ifdef OPENSSL_NPN_NEGOTIATED
+#if defined(OPENSSL_NPN_NEGOTIATED) && !defined(OPENSSL_NO_NEXTPROTONEG)
     unsigned char *npn_protocols;
     int npn_protocols_len;
 #endif
@@ -1502,7 +1502,7 @@ static PyObject *PySSL_version(PySSLSocket *self)
     return PyUnicode_FromString(version);
 }
 
-#ifdef OPENSSL_NPN_NEGOTIATED
+#if defined(OPENSSL_NPN_NEGOTIATED) && !defined(OPENSSL_NO_NEXTPROTONEG)
 static PyObject *PySSL_selected_npn_protocol(PySSLSocket *self) {
     const unsigned char *out;
     unsigned int outlen;
@@ -2140,7 +2140,7 @@ context_new(PyTypeObject *type, PyObject *args, PyObject *kwds)
         return NULL;
     }
     self->ctx = ctx;
-#ifdef OPENSSL_NPN_NEGOTIATED
+#if defined(OPENSSL_NPN_NEGOTIATED) && !defined(OPENSSL_NO_NEXTPROTONEG)
     self->npn_protocols = NULL;
 #endif
 #ifdef HAVE_ALPN
@@ -2218,7 +2218,7 @@ context_dealloc(PySSLContext *self)
     PyObject_GC_UnTrack(self);
     context_clear(self);
     SSL_CTX_free(self->ctx);
-#ifdef OPENSSL_NPN_NEGOTIATED
+#if defined(OPENSSL_NPN_NEGOTIATED) && !defined(OPENSSL_NO_NEXTPROTONEG)
     PyMem_FREE(self->npn_protocols);
 #endif
 #ifdef HAVE_ALPN
@@ -2248,7 +2248,7 @@ set_ciphers(PySSLContext *self, PyObject *args)
     Py_RETURN_NONE;
 }
 
-#ifdef OPENSSL_NPN_NEGOTIATED
+#if defined(OPENSSL_NPN_NEGOTIATED) && !defined(OPENSSL_NO_NEXTPROTONEG) || defined(HAVE_ALPN)
 static int
 do_protocol_selection(int alpn, unsigned char **out, unsigned char *outlen,
                       const unsigned char *server_protocols, unsigned int server_protocols_len,
@@ -2272,7 +2272,9 @@ do_protocol_selection(int alpn, unsigned char **out, unsigned char *outlen,
 
     return SSL_TLSEXT_ERR_OK;
 }
+#endif
 
+#if defined(OPENSSL_NPN_NEGOTIATED) && !defined(OPENSSL_NO_NEXTPROTONEG)
 /* this callback gets passed to SSL_CTX_set_next_protos_advertise_cb */
 static int
 _advertiseNPN_cb(SSL *s,
@@ -2307,7 +2309,7 @@ _selectNPN_cb(SSL *s,
 static PyObject *
 _set_npn_protocols(PySSLContext *self, PyObject *args)
 {
-#ifdef OPENSSL_NPN_NEGOTIATED
+#if defined(OPENSSL_NPN_NEGOTIATED) && !defined(OPENSSL_NO_NEXTPROTONEG)
     Py_buffer protos;
 
     if (!PyArg_ParseTuple(args, "s*:set_npn_protocols", &protos))
@@ -4305,7 +4307,7 @@ init_ssl(void)
     Py_INCREF(r);
     PyModule_AddObject(m, "HAS_ECDH", r);
 
-#ifdef OPENSSL_NPN_NEGOTIATED
+#if defined(OPENSSL_NPN_NEGOTIATED) && !defined(OPENSSL_NO_NEXTPROTONEG)
     r = Py_True;
 #else
     r = Py_False;