diff --git a/Lib/test/test_cmd_line_script.py b/Lib/test/test_cmd_line_script.py
index 2595ca98c7a..4f5af375441 100644
--- a/Lib/test/test_cmd_line_script.py
+++ b/Lib/test/test_cmd_line_script.py
@@ -630,9 +630,13 @@ class CmdLineTest(unittest.TestCase):
             traceback_lines = stderr.decode().splitlines()
             self.assertIn("No module named script_pkg", traceback_lines[-1])
 
+    @unittest.skipIf(sys.platform == 'darwin' and sys._framework,
+                        "test not valid for macOS framework builds")
     def test_nonexisting_script(self):
         # bpo-34783: "./python script.py" must not crash
         # if the script file doesn't exist.
+        # (Skip test for macOS framework builds because sys.excutable name
+        #  is not the actual Python executable file name.
         script = 'nonexistingscript.py'
         self.assertFalse(os.path.exists(script))
         # Only test the base name, since the error message can use