diff --git a/Lib/ctypes/test/test_callbacks.py b/Lib/ctypes/test/test_callbacks.py
index 621a0192b31..901456df19c 100644
--- a/Lib/ctypes/test/test_callbacks.py
+++ b/Lib/ctypes/test/test_callbacks.py
@@ -140,6 +140,14 @@ class Callbacks(unittest.TestCase):
                 if isinstance(x, X)]
         self.assertEqual(len(live), 0)
 
+    def test_issue12483(self):
+        import gc
+        class Nasty:
+            def __del__(self):
+                gc.collect()
+        CFUNCTYPE(None)(lambda x=Nasty(): None)
+        
+
 try:
     WINFUNCTYPE
 except NameError:
diff --git a/Misc/NEWS b/Misc/NEWS
index 41328fd3e83..7984e174e9c 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -192,6 +192,9 @@ Library
 Extension Modules
 -----------------
 
+- Issue #12483: ctypes: Fix a crash when the destruction of a callback
+  object triggers the garbage collector.
+
 - Issue #12950: Fix passing file descriptors in multiprocessing, under
   OpenIndiana/Illumos.
 
diff --git a/Modules/_ctypes/callbacks.c b/Modules/_ctypes/callbacks.c
index 2b54a85b8f3..47dbe05a515 100644
--- a/Modules/_ctypes/callbacks.c
+++ b/Modules/_ctypes/callbacks.c
@@ -18,6 +18,7 @@ static void
 CThunkObject_dealloc(PyObject *_self)
 {
     CThunkObject *self = (CThunkObject *)_self;
+    PyObject_GC_UnTrack(self);
     Py_XDECREF(self->converters);
     Py_XDECREF(self->callable);
     Py_XDECREF(self->restype);