diff --git a/Misc/NEWS.d/next/Core and Builtins/2018-07-07-20-15-34.bpo-34066.y9vs6s.rst b/Misc/NEWS.d/next/Core and Builtins/2018-07-07-20-15-34.bpo-34066.y9vs6s.rst
new file mode 100644
index 00000000000..b12afad8da8
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2018-07-07-20-15-34.bpo-34066.y9vs6s.rst	
@@ -0,0 +1,2 @@
+Disabled interruption by Ctrl-C between calling ``open()`` and entering a
+**with** block in ``with open()``.
diff --git a/Python/ceval.c b/Python/ceval.c
index 422a29ed77d..90ad591dcd8 100644
--- a/Python/ceval.c
+++ b/Python/ceval.c
@@ -928,11 +928,18 @@ main_loop:
            Py_MakePendingCalls() above. */
 
         if (_Py_atomic_load_relaxed(&_PyRuntime.ceval.eval_breaker)) {
-            if (_Py_OPCODE(*next_instr) == SETUP_FINALLY ||
-                _Py_OPCODE(*next_instr) == YIELD_FROM) {
-                /* Two cases where we skip running signal handlers and other
+            opcode = _Py_OPCODE(*next_instr);
+            if (opcode == SETUP_FINALLY ||
+                opcode == SETUP_WITH ||
+                opcode == BEFORE_ASYNC_WITH ||
+                opcode == YIELD_FROM) {
+                /* Few cases where we skip running signal handlers and other
                    pending calls:
-                   - If we're about to enter the try: of a try/finally (not
+                   - If we're about to enter the 'with:'. It will prevent
+                     emitting a resource warning in the common idiom
+                     'with open(path) as file:'.
+                   - If we're about to enter the 'async with:'.
+                   - If we're about to enter the 'try:' of a try/finally (not
                      *very* useful, but might help in some cases and it's
                      traditional)
                    - If we're resuming a chain of nested 'yield from' or