diff --git a/Modules/_ctypes/callbacks.c b/Modules/_ctypes/callbacks.c
index 55ba5f0c0b3..c091d88364a 100644
--- a/Modules/_ctypes/callbacks.c
+++ b/Modules/_ctypes/callbacks.c
@@ -348,7 +348,9 @@ void init_callbacks_in_module(PyObject *m)
 static void LoadPython(void)
 {
 	if (!Py_IsInitialized()) {
+#ifdef WITH_THREAD
 		PyEval_InitThreads();
+#endif
 		Py_Initialize();
 	}
 }
diff --git a/Modules/_ctypes/callproc.c b/Modules/_ctypes/callproc.c
index 0fe7d103ffc..6342ece10d7 100644
--- a/Modules/_ctypes/callproc.c
+++ b/Modules/_ctypes/callproc.c
@@ -818,7 +818,9 @@ GetComError(HRESULT errcode, GUID *riid, IUnknown *pIunk)
 	/* We absolutely have to release the GIL during COM method calls,
 	   otherwise we may get a deadlock!
 	*/
+#ifdef WITH_THREAD
 	Py_BEGIN_ALLOW_THREADS
+#endif
 
 	hr = pIunk->lpVtbl->QueryInterface(pIunk, &IID_ISupportErrorInfo, (void **)&psei);
 	if (FAILED(hr))
@@ -842,7 +844,9 @@ GetComError(HRESULT errcode, GUID *riid, IUnknown *pIunk)
 	pei->lpVtbl->Release(pei);
 
   failed:
+#ifdef WITH_THREAD
 	Py_END_ALLOW_THREADS
+#endif
 
 	progid = NULL;
 	ProgIDFromCLSID(&guid, &progid);