diff --git a/Misc/NEWS.d/next/Core and Builtins/2022-02-01-14-30-56.bpo-45773.Up77LD.rst b/Misc/NEWS.d/next/Core and Builtins/2022-02-01-14-30-56.bpo-45773.Up77LD.rst
new file mode 100644
index 00000000000..45da5116fc9
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2022-02-01-14-30-56.bpo-45773.Up77LD.rst	
@@ -0,0 +1 @@
+Remove two invalid "peephole" optimizations from the bytecode compiler.
diff --git a/Python/compile.c b/Python/compile.c
index 1d2d567e85e..cecd6a5c426 100644
--- a/Python/compile.c
+++ b/Python/compile.c
@@ -8757,7 +8757,6 @@ optimize_basic_block(struct compiler *c, basicblock *bb, PyObject *consts)
                 switch (target->i_opcode) {
                     case JUMP_ABSOLUTE:
                     case JUMP_FORWARD:
-                    case JUMP_IF_FALSE_OR_POP:
                         i -= jump_thread(inst, target, POP_JUMP_IF_FALSE);
                 }
                 break;
@@ -8765,7 +8764,6 @@ optimize_basic_block(struct compiler *c, basicblock *bb, PyObject *consts)
                 switch (target->i_opcode) {
                     case JUMP_ABSOLUTE:
                     case JUMP_FORWARD:
-                    case JUMP_IF_TRUE_OR_POP:
                         i -= jump_thread(inst, target, POP_JUMP_IF_TRUE);
                 }
                 break;