diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2024-11-01-09-58-06.gh-issue-103951.6qduwj.rst b/Misc/NEWS.d/next/Core_and_Builtins/2024-11-01-09-58-06.gh-issue-103951.6qduwj.rst
new file mode 100644
index 00000000000..39b54e0b725
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2024-11-01-09-58-06.gh-issue-103951.6qduwj.rst
@@ -0,0 +1,2 @@
+Relax optimization requirements to allow fast attribute access to module
+subclasses.
diff --git a/Python/bytecodes.c b/Python/bytecodes.c
index 04983fd861e..c85b49842da 100644
--- a/Python/bytecodes.c
+++ b/Python/bytecodes.c
@@ -2132,7 +2132,7 @@ dummy_func(
 
         op(_CHECK_ATTR_MODULE, (dict_version/2, owner -- owner)) {
             PyObject *owner_o = PyStackRef_AsPyObjectBorrow(owner);
-            DEOPT_IF(!PyModule_CheckExact(owner_o));
+            DEOPT_IF(Py_TYPE(owner_o)->tp_getattro != PyModule_Type.tp_getattro);
             PyDictObject *dict = (PyDictObject *)((PyModuleObject *)owner_o)->md_dict;
             assert(dict != NULL);
             DEOPT_IF(dict->ma_keys->dk_version != dict_version);
diff --git a/Python/executor_cases.c.h b/Python/executor_cases.c.h
index 494ace1bd85..2c2a09adf28 100644
--- a/Python/executor_cases.c.h
+++ b/Python/executor_cases.c.h
@@ -2602,7 +2602,7 @@
             owner = stack_pointer[-1];
             uint32_t dict_version = (uint32_t)CURRENT_OPERAND0();
             PyObject *owner_o = PyStackRef_AsPyObjectBorrow(owner);
-            if (!PyModule_CheckExact(owner_o)) {
+            if (Py_TYPE(owner_o)->tp_getattro != PyModule_Type.tp_getattro) {
                 UOP_STAT_INC(uopcode, miss);
                 JUMP_TO_JUMP_TARGET();
             }
diff --git a/Python/generated_cases.c.h b/Python/generated_cases.c.h
index 77bf6ad3781..15308d6f1f7 100644
--- a/Python/generated_cases.c.h
+++ b/Python/generated_cases.c.h
@@ -5561,7 +5561,7 @@
                 owner = stack_pointer[-1];
                 uint32_t dict_version = read_u32(&this_instr[2].cache);
                 PyObject *owner_o = PyStackRef_AsPyObjectBorrow(owner);
-                DEOPT_IF(!PyModule_CheckExact(owner_o), LOAD_ATTR);
+                DEOPT_IF(Py_TYPE(owner_o)->tp_getattro != PyModule_Type.tp_getattro, LOAD_ATTR);
                 PyDictObject *dict = (PyDictObject *)((PyModuleObject *)owner_o)->md_dict;
                 assert(dict != NULL);
                 DEOPT_IF(dict->ma_keys->dk_version != dict_version, LOAD_ATTR);
diff --git a/Python/specialize.c b/Python/specialize.c
index 0699e7be5e6..4c8cf8534b3 100644
--- a/Python/specialize.c
+++ b/Python/specialize.c
@@ -1219,7 +1219,7 @@ _Py_Specialize_LoadAttr(_PyStackRef owner_st, _Py_CODEUNIT *instr, PyObject *nam
         SPECIALIZATION_FAIL(LOAD_ATTR, SPEC_FAIL_OTHER);
         fail = true;
     }
-    else if (PyModule_CheckExact(owner)) {
+    else if (Py_TYPE(owner)->tp_getattro == PyModule_Type.tp_getattro) {
         fail = specialize_module_load_attr(owner, instr, name);
     }
     else if (PyType_Check(owner)) {