diff --git a/Lib/test/libregrtest/utils.py b/Lib/test/libregrtest/utils.py
index 0167742d388..f4d3b005af8 100644
--- a/Lib/test/libregrtest/utils.py
+++ b/Lib/test/libregrtest/utils.py
@@ -264,6 +264,12 @@ def clear_caches():
         for f in typing._cleanups:
             f()
 
+        import inspect
+        abs_classes = filter(inspect.isabstract, typing.__dict__.values())
+        for abc in abs_classes:
+            for obj in abc.__subclasses__() + [abc]:
+                obj._abc_caches_clear()
+
     try:
         fractions = sys.modules['fractions']
     except KeyError:
diff --git a/Misc/NEWS.d/next/Tests/2024-07-04-15-10-29.gh-issue-121084.qxcd5d.rst b/Misc/NEWS.d/next/Tests/2024-07-04-15-10-29.gh-issue-121084.qxcd5d.rst
new file mode 100644
index 00000000000..b91ea8acfad
--- /dev/null
+++ b/Misc/NEWS.d/next/Tests/2024-07-04-15-10-29.gh-issue-121084.qxcd5d.rst
@@ -0,0 +1,3 @@
+Fix test_typing random leaks. Clear typing ABC caches when running tests for
+refleaks (``-R`` option): call ``_abc_caches_clear()`` on typing abstract
+classes and their subclasses. Patch by Victor Stinner.