diff --git a/Modules/_uuidmodule.c b/Modules/_uuidmodule.c
index 88c40ce3537..d4bc3c7b0d4 100644
--- a/Modules/_uuidmodule.c
+++ b/Modules/_uuidmodule.c
@@ -4,17 +4,10 @@
 #include <uuid/uuid.h>
 
 
-/* bpo-11063: libuuid on macOS doesn't provide uuid_generate_time_safe(),
-   only uuid_generate_time(). */
-#ifndef __APPLE__
-#  define HAVE_TIME_SAFE
-#endif
-
-
 static PyObject *
 py_uuid_generate_time_safe(void)
 {
-#ifdef HAVE_TIME_SAFE
+#ifdef HAVE_UUID_GENERATE_TIME_SAFE
     uuid_t out;
     int res;
 
@@ -45,7 +38,7 @@ PyInit__uuid(void)
 {
     PyObject *mod;
     assert(sizeof(uuid_t) == 16);
-#ifdef HAVE_TIME_SAFE
+#ifdef HAVE_UUID_GENERATE_TIME_SAFE
     int has_uuid_generate_time_safe = 1;
 #else
     int has_uuid_generate_time_safe = 0;
diff --git a/configure b/configure
index 0edbb3e8623..7944f8fe5d4 100755
--- a/configure
+++ b/configure
@@ -9512,6 +9512,37 @@ _ACEOF
 fi
 	# Dynamic linking for HP-UX
 
+{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for uuid_generate_time_safe" >&5
+$as_echo_n "checking for uuid_generate_time_safe... " >&6; }
+cat confdefs.h - <<_ACEOF >conftest.$ac_ext
+/* end confdefs.h.  */
+#include <uuid/uuid.h>
+int
+main ()
+{
+
+#ifndef uuid_generate_time_safe
+uuid_t out;
+uuid_generate_time_safe(out);
+#endif
+
+  ;
+  return 0;
+}
+_ACEOF
+if ac_fn_c_try_compile "$LINENO"; then :
+
+$as_echo "#define HAVE_UUID_GENERATE_TIME_SAFE 1" >>confdefs.h
+
+   { $as_echo "$as_me:${as_lineno-$LINENO}: result: yes" >&5
+$as_echo "yes" >&6; }
+else
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5
+$as_echo "no" >&6; }
+
+fi
+rm -f core conftest.err conftest.$ac_objext conftest.$ac_ext
+
 { $as_echo "$as_me:${as_lineno-$LINENO}: checking for library containing sem_init" >&5
 $as_echo_n "checking for library containing sem_init... " >&6; }
 if ${ac_cv_search_sem_init+:} false; then :
diff --git a/configure.ac b/configure.ac
index c7738064582..743e0625dc4 100644
--- a/configure.ac
+++ b/configure.ac
@@ -2677,6 +2677,18 @@ AC_CHECK_LIB(sendfile, sendfile)
 AC_CHECK_LIB(dl, dlopen)	# Dynamic linking for SunOS/Solaris and SYSV
 AC_CHECK_LIB(dld, shl_load)	# Dynamic linking for HP-UX
 
+AC_MSG_CHECKING(for uuid_generate_time_safe)
+AC_COMPILE_IFELSE([AC_LANG_PROGRAM([[#include <uuid/uuid.h>]], [[
+#ifndef uuid_generate_time_safe
+uuid_t out;
+uuid_generate_time_safe(out);
+#endif
+]])],
+  [AC_DEFINE(HAVE_UUID_GENERATE_TIME_SAFE, 1, Define if uuid_generate_time_safe() exists.)
+   AC_MSG_RESULT(yes)],
+  [AC_MSG_RESULT(no)]
+)
+
 AC_SEARCH_LIBS(sem_init, pthread rt posix4) 	# 'Real Time' functions on Solaris
 						# posix4 on Solaris 2.6
 						# pthread (first!) on Linux
diff --git a/pyconfig.h.in b/pyconfig.h.in
index 5f8b09a6189..6e0f3e8eeb3 100644
--- a/pyconfig.h.in
+++ b/pyconfig.h.in
@@ -1187,6 +1187,9 @@
 /* Define to 1 if you have the <utime.h> header file. */
 #undef HAVE_UTIME_H
 
+/* Define if uuid_generate_time_safe() exists. */
+#undef HAVE_UUID_GENERATE_TIME_SAFE
+
 /* Define to 1 if you have the `wait3' function. */
 #undef HAVE_WAIT3