diff --git a/Lib/test/test_capi/test_misc.py b/Lib/test/test_capi/test_misc.py
index 1cd4c56b49b..4148f15b2aa 100644
--- a/Lib/test/test_capi/test_misc.py
+++ b/Lib/test/test_capi/test_misc.py
@@ -2478,7 +2478,7 @@ class TestUops(unittest.TestCase):
 
         opt = _testinternalcapi.get_uop_optimizer()
         with temporary_optimizer(opt):
-            testfunc([1, 2, 3])
+            testfunc(range(10))
 
         ex = get_first_executor(testfunc)
         self.assertIsNotNone(ex)
@@ -2493,7 +2493,7 @@ class TestUops(unittest.TestCase):
 
         opt = _testinternalcapi.get_uop_optimizer()
         with temporary_optimizer(opt):
-            testfunc([1, 2, 3])
+            testfunc(range(10))
 
         ex = get_first_executor(testfunc)
         self.assertIsNotNone(ex)
diff --git a/Misc/NEWS.d/next/Core and Builtins/2023-08-28-22-22-15.gh-issue-108488.e8-fxg.rst b/Misc/NEWS.d/next/Core and Builtins/2023-08-28-22-22-15.gh-issue-108488.e8-fxg.rst
new file mode 100644
index 00000000000..f9d6f593b8e
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2023-08-28-22-22-15.gh-issue-108488.e8-fxg.rst	
@@ -0,0 +1 @@
+Change the initialization of inline cache entries so that the cache entry for ``JUMP_BACKWARD`` is initialized to zero, instead of the ``adaptive_counter_warmup()`` value used for all other instructions. This counter, unique among instructions, counts up from zero.
diff --git a/Python/specialize.c b/Python/specialize.c
index a467f163f2c..a794f146c18 100644
--- a/Python/specialize.c
+++ b/Python/specialize.c
@@ -302,7 +302,9 @@ _PyCode_Quicken(PyCodeObject *code)
         assert(opcode < MIN_INSTRUMENTED_OPCODE);
         int caches = _PyOpcode_Caches[opcode];
         if (caches) {
-            instructions[i + 1].cache = adaptive_counter_warmup();
+            // JUMP_BACKWARD counter counts up from 0 until it is > backedge_threshold
+            instructions[i + 1].cache =
+                opcode == JUMP_BACKWARD ? 0 : adaptive_counter_warmup();
             i += caches;
         }
     }