diff --git a/Misc/NEWS.d/next/C API/2024-07-04-13-23-27.gh-issue-113601.K3RLqp.rst b/Misc/NEWS.d/next/C API/2024-07-04-13-23-27.gh-issue-113601.K3RLqp.rst
new file mode 100644
index 00000000000..009cc2bf017
--- /dev/null
+++ b/Misc/NEWS.d/next/C API/2024-07-04-13-23-27.gh-issue-113601.K3RLqp.rst	
@@ -0,0 +1,2 @@
+Removed debug build assertions related to interning strings, which were
+falsely triggered by stable ABI extensions.
diff --git a/Objects/unicodeobject.c b/Objects/unicodeobject.c
index b21886e22c1..c7bd474c1e3 100644
--- a/Objects/unicodeobject.c
+++ b/Objects/unicodeobject.c
@@ -247,7 +247,8 @@ _PyUnicode_InternedSize_Immortal(void)
     // value, to help detect bugs in optimizations.
 
     while (PyDict_Next(dict, &pos, &key, &value)) {
-       if (_Py_IsImmortal(key)) {
+        assert(PyUnicode_CHECK_INTERNED(key) != SSTATE_INTERNED_IMMORTAL_STATIC);
+        if (PyUnicode_CHECK_INTERNED(key) == SSTATE_INTERNED_IMMORTAL) {
            count++;
        }
     }
@@ -683,10 +684,14 @@ _PyUnicode_CheckConsistency(PyObject *op, int check_content)
 
     /* Check interning state */
 #ifdef Py_DEBUG
+    // Note that we do not check `_Py_IsImmortal(op)`, since stable ABI
+    // extensions can make immortal strings mortal (but with a high enough
+    // refcount).
+    // The other way is extremely unlikely (worth a potential failed assertion
+    // in a debug build), so we do check `!_Py_IsImmortal(op)`.
     switch (PyUnicode_CHECK_INTERNED(op)) {
         case SSTATE_NOT_INTERNED:
             if (ascii->state.statically_allocated) {
-                CHECK(_Py_IsImmortal(op));
                 // This state is for two exceptions:
                 // - strings are currently checked before they're interned
                 // - the 256 one-latin1-character strings
@@ -702,11 +707,9 @@ _PyUnicode_CheckConsistency(PyObject *op, int check_content)
             break;
         case SSTATE_INTERNED_IMMORTAL:
             CHECK(!ascii->state.statically_allocated);
-            CHECK(_Py_IsImmortal(op));
             break;
         case SSTATE_INTERNED_IMMORTAL_STATIC:
             CHECK(ascii->state.statically_allocated);
-            CHECK(_Py_IsImmortal(op));
             break;
         default:
             Py_UNREACHABLE();
@@ -1899,7 +1902,6 @@ static PyObject*
 get_latin1_char(Py_UCS1 ch)
 {
     PyObject *o = LATIN1(ch);
-    assert(_Py_IsImmortal(o));
     return o;
 }
 
@@ -15049,7 +15051,6 @@ intern_static(PyInterpreterState *interp, PyObject *s /* stolen */)
     assert(s != NULL);
     assert(_PyUnicode_CHECK(s));
     assert(_PyUnicode_STATE(s).statically_allocated);
-    assert(_Py_IsImmortal(s));
 
     switch (PyUnicode_CHECK_INTERNED(s)) {
         case SSTATE_NOT_INTERNED:
@@ -15190,7 +15191,7 @@ intern_common(PyInterpreterState *interp, PyObject *s /* stolen */,
     {
         PyObject *r = (PyObject *)_Py_hashtable_get(INTERNED_STRINGS, s);
         if (r != NULL) {
-            assert(_Py_IsImmortal(r));
+            assert(_PyUnicode_STATE(r).statically_allocated);
             assert(r != s);  // r must be statically_allocated; s is not
             Py_DECREF(s);
             return Py_NewRef(r);