diff --git a/Lib/ctypes/test/test_structures.py b/Lib/ctypes/test/test_structures.py
index 3eded7749ed..2e778fb1b43 100644
--- a/Lib/ctypes/test/test_structures.py
+++ b/Lib/ctypes/test/test_structures.py
@@ -2,8 +2,8 @@ import unittest
 from ctypes import *
 from ctypes.test import need_symbol
 from struct import calcsize
-import _testcapi
 import _ctypes_test
+import test.support
 
 class SubclassesTest(unittest.TestCase):
     def test_subclass(self):
@@ -202,7 +202,10 @@ class StructureTestCase(unittest.TestCase):
              "_pack_": -1}
         self.assertRaises(ValueError, type(Structure), "X", (Structure,), d)
 
+    @test.support.cpython_only
+    def test_packed_c_limits(self):
         # Issue 15989
+        import _testcapi
         d = {"_fields_": [("a", c_byte)],
              "_pack_": _testcapi.INT_MAX + 1}
         self.assertRaises(ValueError, type(Structure), "X", (Structure,), d)
diff --git a/Lib/test/test_atexit.py b/Lib/test/test_atexit.py
index 172bd25419c..c761076c4a0 100644
--- a/Lib/test/test_atexit.py
+++ b/Lib/test/test_atexit.py
@@ -143,6 +143,7 @@ class GeneralTest(unittest.TestCase):
         self.assertEqual(l, [5])
 
 
+@support.cpython_only
 class SubinterpreterTest(unittest.TestCase):
 
     def test_callbacks_leak(self):
diff --git a/Lib/test/test_coroutines.py b/Lib/test/test_coroutines.py
index a69583b5f95..2b79a17ea70 100644
--- a/Lib/test/test_coroutines.py
+++ b/Lib/test/test_coroutines.py
@@ -2117,6 +2117,7 @@ class SysSetCoroWrapperTest(unittest.TestCase):
             sys.set_coroutine_wrapper(None)
 
 
+@support.cpython_only
 class CAPITest(unittest.TestCase):
 
     def test_tp_await_1(self):
diff --git a/Lib/test/test_socket.py b/Lib/test/test_socket.py
index f8e5b369ef2..7cc2e57b0dd 100644
--- a/Lib/test/test_socket.py
+++ b/Lib/test/test_socket.py
@@ -906,6 +906,7 @@ class GeneralModuleTests(unittest.TestCase):
             self.assertEqual(swapped & mask, mask)
             self.assertRaises(OverflowError, func, 1<<34)
 
+    @support.cpython_only
     def testNtoHErrors(self):
         import _testcapi
         s_good_values = [0, 1, 2, 0xffff]
diff --git a/Lib/test/test_tracemalloc.py b/Lib/test/test_tracemalloc.py
index 790ab7ee606..742259b4396 100644
--- a/Lib/test/test_tracemalloc.py
+++ b/Lib/test/test_tracemalloc.py
@@ -865,6 +865,7 @@ class TestCommandLine(unittest.TestCase):
                                   b'number of frames',
                                   stderr)
 
+    @unittest.skipIf(_testcapi is None, 'need _testcapi')
     def test_pymem_alloc0(self):
         # Issue #21639: Check that PyMem_Malloc(0) with tracemalloc enabled
         # does not crash.