diff --git a/Include/object.h b/Include/object.h
index 36d63afc882..ad58450fb91 100644
--- a/Include/object.h
+++ b/Include/object.h
@@ -632,7 +632,6 @@ given type object has a specified feature.
 #define Py_TPFLAGS_IS_ABSTRACT (1UL << 20)
 
 /* These flags are used to determine if a type is a subclass. */
-#define Py_TPFLAGS_INT_SUBCLASS         (1UL << 23)
 #define Py_TPFLAGS_LONG_SUBCLASS        (1UL << 24)
 #define Py_TPFLAGS_LIST_SUBCLASS        (1UL << 25)
 #define Py_TPFLAGS_TUPLE_SUBCLASS       (1UL << 26)
diff --git a/Misc/NEWS b/Misc/NEWS
index 3e48036d38a..e3f502473ba 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -10,6 +10,8 @@ What's New in Python 3.4.0 Alpha 1?
 Core and Builtins
 -----------------
 
+- Issue #16505: Remove unused Py_TPFLAGS_INT_SUBCLASS.
+
 - Issue #16306: Fix multiple error messages when unknown command line
   parameters where passed to the interpreter.  Patch by Hieu Nguyen.