diff --git a/Parser/asdl_c.py b/Parser/asdl_c.py
index 40b84996a1b..1508e839fe2 100755
--- a/Parser/asdl_c.py
+++ b/Parser/asdl_c.py
@@ -367,6 +367,7 @@ class Obj2ModVisitor(PickleVisitor):
         self.emit("obj2ast_%s(PyObject* obj, %s* out, PyArena* arena)" % (name, ctype), 0)
         self.emit("{", 0)
         self.emit("PyObject* tmp = NULL;", 1)
+        self.emit("int isinstance;", 1)
         self.emit("", 0)
 
     def sumTrailer(self, name):
@@ -386,7 +387,13 @@ class Obj2ModVisitor(PickleVisitor):
     def simpleSum(self, sum, name):
         self.funcHeader(name)
         for t in sum.types:
-            self.emit("if (PyObject_IsInstance(obj, (PyObject*)%s_type)) {" % t.name, 1)
+            line = ("isinstance = PyObject_IsInstance(obj, "
+                    "(PyObject *)%s_type);")
+            self.emit(line % (t.name,), 1)
+            self.emit("if (isinstance == -1) {", 1)
+            self.emit("return 1;", 2)
+            self.emit("}", 1)
+            self.emit("if (isinstance) {", 1)
             self.emit("*out = %s;" % t.name, 2)
             self.emit("return 0;", 2)
             self.emit("}", 1)
@@ -408,7 +415,12 @@ class Obj2ModVisitor(PickleVisitor):
         for a in sum.attributes:
             self.visitField(a, name, sum=sum, depth=1)
         for t in sum.types:
-            self.emit("if (PyObject_IsInstance(obj, (PyObject*)%s_type)) {" % t.name, 1)
+            line = "isinstance = PyObject_IsInstance(obj, (PyObject*)%s_type);"
+            self.emit(line % (t.name,), 1)
+            self.emit("if (isinstance == -1) {", 1)
+            self.emit("return 1;", 2)
+            self.emit("}", 1)
+            self.emit("if (isinstance) {", 1)
             for f in t.fields:
                 self.visitFieldDeclaration(f, t.name, sum=sum, depth=2)
             self.emit("", 0)
@@ -1093,11 +1105,15 @@ mod_ty PyAST_obj2mod(PyObject* ast, PyArena* arena, int mode)
     PyObject *req_type[] = {(PyObject*)Module_type, (PyObject*)Expression_type,
                             (PyObject*)Interactive_type};
     char *req_name[] = {"Module", "Expression", "Interactive"};
+    int isinstance;
     assert(0 <= mode && mode <= 2);
 
     init_types();
 
-    if (!PyObject_IsInstance(ast, req_type[mode])) {
+    isinstance = PyObject_IsInstance(ast, req_type[mode]);
+    if (isinstance == -1)
+        return NULL;
+    if (!isinstance) {
         PyErr_Format(PyExc_TypeError, "expected %s node, got %.400s",
                      req_name[mode], Py_TYPE(ast)->tp_name);
         return NULL;
diff --git a/Python/Python-ast.c b/Python/Python-ast.c
index 9ff3d8aa9f9..61e7427380f 100644
--- a/Python/Python-ast.c
+++ b/Python/Python-ast.c
@@ -3175,13 +3175,18 @@ int
 obj2ast_mod(PyObject* obj, mod_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
 
         if (obj == Py_None) {
                 *out = NULL;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Module_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Module_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* body;
 
                 if (PyObject_HasAttrString(obj, "body")) {
@@ -3213,7 +3218,11 @@ obj2ast_mod(PyObject* obj, mod_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Interactive_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Interactive_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* body;
 
                 if (PyObject_HasAttrString(obj, "body")) {
@@ -3245,7 +3254,11 @@ obj2ast_mod(PyObject* obj, mod_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Expression_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Expression_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty body;
 
                 if (PyObject_HasAttrString(obj, "body")) {
@@ -3264,7 +3277,11 @@ obj2ast_mod(PyObject* obj, mod_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Suite_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Suite_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* body;
 
                 if (PyObject_HasAttrString(obj, "body")) {
@@ -3309,6 +3326,7 @@ int
 obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
         int lineno;
         int col_offset;
@@ -3341,7 +3359,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 PyErr_SetString(PyExc_TypeError, "required field \"col_offset\" missing from stmt");
                 return 1;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)FunctionDef_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)FunctionDef_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 identifier name;
                 arguments_ty args;
                 asdl_seq* body;
@@ -3426,7 +3448,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)ClassDef_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)ClassDef_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 identifier name;
                 asdl_seq* bases;
                 asdl_seq* body;
@@ -3524,7 +3550,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Return_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Return_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
 
                 if (PyObject_HasAttrString(obj, "value")) {
@@ -3542,7 +3572,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Delete_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Delete_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* targets;
 
                 if (PyObject_HasAttrString(obj, "targets")) {
@@ -3574,7 +3608,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Assign_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Assign_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* targets;
                 expr_ty value;
 
@@ -3619,7 +3657,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)AugAssign_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)AugAssign_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty target;
                 operator_ty op;
                 expr_ty value;
@@ -3664,7 +3706,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Print_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Print_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty dest;
                 asdl_seq* values;
                 bool nl;
@@ -3721,7 +3767,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)For_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)For_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty target;
                 expr_ty iter;
                 asdl_seq* body;
@@ -3806,7 +3856,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)While_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)While_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty test;
                 asdl_seq* body;
                 asdl_seq* orelse;
@@ -3877,7 +3931,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)If_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)If_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty test;
                 asdl_seq* body;
                 asdl_seq* orelse;
@@ -3948,7 +4006,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)With_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)With_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty context_expr;
                 expr_ty optional_vars;
                 asdl_seq* body;
@@ -4006,7 +4068,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Raise_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Raise_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty type;
                 expr_ty inst;
                 expr_ty tback;
@@ -4048,7 +4114,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)TryExcept_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)TryExcept_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* body;
                 asdl_seq* handlers;
                 asdl_seq* orelse;
@@ -4133,7 +4203,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)TryFinally_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)TryFinally_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* body;
                 asdl_seq* finalbody;
 
@@ -4191,7 +4265,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Assert_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Assert_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty test;
                 expr_ty msg;
 
@@ -4222,7 +4300,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Import_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Import_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* names;
 
                 if (PyObject_HasAttrString(obj, "names")) {
@@ -4254,7 +4336,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)ImportFrom_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)ImportFrom_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 identifier module;
                 asdl_seq* names;
                 int level;
@@ -4311,7 +4397,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Exec_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Exec_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty body;
                 expr_ty globals;
                 expr_ty locals;
@@ -4354,7 +4444,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Global_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Global_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* names;
 
                 if (PyObject_HasAttrString(obj, "names")) {
@@ -4386,7 +4480,11 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Expr_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Expr_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
 
                 if (PyObject_HasAttrString(obj, "value")) {
@@ -4405,19 +4503,31 @@ obj2ast_stmt(PyObject* obj, stmt_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Pass_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Pass_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
 
                 *out = Pass(lineno, col_offset, arena);
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Break_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Break_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
 
                 *out = Break(lineno, col_offset, arena);
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Continue_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Continue_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
 
                 *out = Continue(lineno, col_offset, arena);
                 if (*out == NULL) goto failed;
@@ -4436,6 +4546,7 @@ int
 obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
         int lineno;
         int col_offset;
@@ -4468,7 +4579,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 PyErr_SetString(PyExc_TypeError, "required field \"col_offset\" missing from expr");
                 return 1;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)BoolOp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)BoolOp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 boolop_ty op;
                 asdl_seq* values;
 
@@ -4513,7 +4628,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)BinOp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)BinOp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty left;
                 operator_ty op;
                 expr_ty right;
@@ -4558,7 +4677,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)UnaryOp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)UnaryOp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 unaryop_ty op;
                 expr_ty operand;
 
@@ -4590,7 +4713,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Lambda_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Lambda_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 arguments_ty args;
                 expr_ty body;
 
@@ -4622,7 +4749,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)IfExp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)IfExp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty test;
                 expr_ty body;
                 expr_ty orelse;
@@ -4667,7 +4798,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Dict_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Dict_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* keys;
                 asdl_seq* values;
 
@@ -4725,7 +4860,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)ListComp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)ListComp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty elt;
                 asdl_seq* generators;
 
@@ -4770,7 +4909,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)GeneratorExp_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)GeneratorExp_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty elt;
                 asdl_seq* generators;
 
@@ -4815,7 +4958,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Yield_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Yield_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
 
                 if (PyObject_HasAttrString(obj, "value")) {
@@ -4833,7 +4980,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Compare_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Compare_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty left;
                 asdl_int_seq* ops;
                 asdl_seq* comparators;
@@ -4905,7 +5056,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Call_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Call_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty func;
                 asdl_seq* args;
                 asdl_seq* keywords;
@@ -5001,7 +5156,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Repr_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Repr_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
 
                 if (PyObject_HasAttrString(obj, "value")) {
@@ -5020,7 +5179,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Num_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Num_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 object n;
 
                 if (PyObject_HasAttrString(obj, "n")) {
@@ -5039,7 +5202,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Str_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Str_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 string s;
 
                 if (PyObject_HasAttrString(obj, "s")) {
@@ -5058,7 +5225,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Attribute_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Attribute_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
                 identifier attr;
                 expr_context_ty ctx;
@@ -5103,7 +5274,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Subscript_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Subscript_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
                 slice_ty slice;
                 expr_context_ty ctx;
@@ -5148,7 +5323,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Name_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Name_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 identifier id;
                 expr_context_ty ctx;
 
@@ -5180,7 +5359,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)List_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)List_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* elts;
                 expr_context_ty ctx;
 
@@ -5225,7 +5408,11 @@ obj2ast_expr(PyObject* obj, expr_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Tuple_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Tuple_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* elts;
                 expr_context_ty ctx;
 
@@ -5283,28 +5470,53 @@ int
 obj2ast_expr_context(PyObject* obj, expr_context_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
-        if (PyObject_IsInstance(obj, (PyObject*)Load_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Load_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Load;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Store_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Store_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Store;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Del_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Del_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Del;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)AugLoad_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)AugLoad_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = AugLoad;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)AugStore_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)AugStore_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = AugStore;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Param_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Param_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Param;
                 return 0;
         }
@@ -5321,19 +5533,28 @@ int
 obj2ast_slice(PyObject* obj, slice_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
 
         if (obj == Py_None) {
                 *out = NULL;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Ellipsis_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Ellipsis_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
 
                 *out = Ellipsis(arena);
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Slice_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Slice_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty lower;
                 expr_ty upper;
                 expr_ty step;
@@ -5375,7 +5596,11 @@ obj2ast_slice(PyObject* obj, slice_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)ExtSlice_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)ExtSlice_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 asdl_seq* dims;
 
                 if (PyObject_HasAttrString(obj, "dims")) {
@@ -5407,7 +5632,11 @@ obj2ast_slice(PyObject* obj, slice_ty* out, PyArena* arena)
                 if (*out == NULL) goto failed;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Index_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)Index_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty value;
 
                 if (PyObject_HasAttrString(obj, "value")) {
@@ -5439,12 +5668,21 @@ int
 obj2ast_boolop(PyObject* obj, boolop_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
-        if (PyObject_IsInstance(obj, (PyObject*)And_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)And_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = And;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Or_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Or_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Or;
                 return 0;
         }
@@ -5461,52 +5699,101 @@ int
 obj2ast_operator(PyObject* obj, operator_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
-        if (PyObject_IsInstance(obj, (PyObject*)Add_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Add_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Add;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Sub_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Sub_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Sub;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Mult_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Mult_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Mult;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Div_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Div_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Div;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Mod_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Mod_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Mod;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Pow_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Pow_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Pow;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)LShift_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)LShift_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = LShift;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)RShift_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)RShift_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = RShift;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)BitOr_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)BitOr_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = BitOr;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)BitXor_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)BitXor_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = BitXor;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)BitAnd_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)BitAnd_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = BitAnd;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)FloorDiv_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)FloorDiv_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = FloorDiv;
                 return 0;
         }
@@ -5523,20 +5810,37 @@ int
 obj2ast_unaryop(PyObject* obj, unaryop_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
-        if (PyObject_IsInstance(obj, (PyObject*)Invert_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Invert_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Invert;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Not_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Not_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Not;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)UAdd_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)UAdd_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = UAdd;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)USub_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)USub_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = USub;
                 return 0;
         }
@@ -5553,44 +5857,85 @@ int
 obj2ast_cmpop(PyObject* obj, cmpop_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
-        if (PyObject_IsInstance(obj, (PyObject*)Eq_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Eq_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Eq;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)NotEq_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)NotEq_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = NotEq;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Lt_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Lt_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Lt;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)LtE_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)LtE_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = LtE;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Gt_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Gt_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Gt;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)GtE_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)GtE_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = GtE;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)Is_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)Is_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = Is;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)IsNot_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)IsNot_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = IsNot;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)In_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)In_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = In;
                 return 0;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)NotIn_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject *)NotIn_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 *out = NotIn;
                 return 0;
         }
@@ -5671,6 +6016,7 @@ int
 obj2ast_excepthandler(PyObject* obj, excepthandler_ty* out, PyArena* arena)
 {
         PyObject* tmp = NULL;
+        int isinstance;
 
         int lineno;
         int col_offset;
@@ -5703,7 +6049,11 @@ obj2ast_excepthandler(PyObject* obj, excepthandler_ty* out, PyArena* arena)
                 PyErr_SetString(PyExc_TypeError, "required field \"col_offset\" missing from excepthandler");
                 return 1;
         }
-        if (PyObject_IsInstance(obj, (PyObject*)ExceptHandler_type)) {
+        isinstance = PyObject_IsInstance(obj, (PyObject*)ExceptHandler_type);
+        if (isinstance == -1) {
+                return 1;
+        }
+        if (isinstance) {
                 expr_ty type;
                 expr_ty name;
                 asdl_seq* body;
@@ -6104,11 +6454,15 @@ mod_ty PyAST_obj2mod(PyObject* ast, PyArena* arena, int mode)
     PyObject *req_type[] = {(PyObject*)Module_type, (PyObject*)Expression_type,
                             (PyObject*)Interactive_type};
     char *req_name[] = {"Module", "Expression", "Interactive"};
+    int isinstance;
     assert(0 <= mode && mode <= 2);
 
     init_types();
 
-    if (!PyObject_IsInstance(ast, req_type[mode])) {
+    isinstance = PyObject_IsInstance(ast, req_type[mode]);
+    if (isinstance == -1)
+        return NULL;
+    if (!isinstance) {
         PyErr_Format(PyExc_TypeError, "expected %s node, got %.400s",
                      req_name[mode], Py_TYPE(ast)->tp_name);
         return NULL;
diff --git a/Python/bltinmodule.c b/Python/bltinmodule.c
index b201aaf7877..3132cf4b41b 100644
--- a/Python/bltinmodule.c
+++ b/Python/bltinmodule.c
@@ -466,6 +466,7 @@ builtin_compile(PyObject *self, PyObject *args, PyObject *kwds)
 	int mode = -1;
 	int dont_inherit = 0;
 	int supplied_flags = 0;
+	int is_ast;
 	PyCompilerFlags cf;
 	PyObject *result = NULL, *cmd, *tmp = NULL;
 	Py_ssize_t length;
@@ -505,7 +506,10 @@ builtin_compile(PyObject *self, PyObject *args, PyObject *kwds)
 		return NULL;
 	}
 
-	if (PyAST_Check(cmd)) {
+	is_ast = PyAST_Check(cmd);
+	if (is_ast == -1)
+		return NULL;
+	if (is_ast) {
 		if (supplied_flags & PyCF_ONLY_AST) {
 			Py_INCREF(cmd);
 			result = cmd;