diff --git a/Misc/NEWS b/Misc/NEWS
index be6a1197c5a..d39e65c6fd6 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -307,6 +307,8 @@ Tests
 Build
 -----
 
+- Issue #17791: Drop PREFIX and EXEC_PREFIX definitions from PC/pyconfig.h
+
 - Add workaround for VS 2010 nmake clean issue. VS 2010 doesn't set up PATH
   for nmake.exe correctly.
 
diff --git a/PC/pyconfig.h b/PC/pyconfig.h
index 8b3d60f2f16..299527db7d4 100644
--- a/PC/pyconfig.h
+++ b/PC/pyconfig.h
@@ -74,8 +74,6 @@ WIN32 is still required for the locale module.
 #define DONT_HAVE_SIG_PAUSE
 #define LONG_BIT	32
 #define WORD_BIT 32
-#define PREFIX ""
-#define EXEC_PREFIX ""
 
 #define MS_WIN32 /* only support win32 and greater. */
 #define MS_WINDOWS