diff --git a/Misc/NEWS b/Misc/NEWS
index 36bf9c35a26..0203e6cec40 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -115,6 +115,8 @@ Tests
 Build
 -----
 
+- Add missing PGI/PGO configurations for pywlauncher.
+
 - Issue #15645: Ensure 2to3 grammar pickles are properly installed.
 
 
diff --git a/PCbuild/pcbuild.sln b/PCbuild/pcbuild.sln
index 48cfb8dce50..d6a022f5178 100644
--- a/PCbuild/pcbuild.sln
+++ b/PCbuild/pcbuild.sln
@@ -582,6 +582,7 @@ Global
 		{7B2727B5-5A3F-40EE-A866-43A13CD31446}.PGUpdate|Win32.ActiveCfg = PGUpdate|Win32
 		{7B2727B5-5A3F-40EE-A866-43A13CD31446}.PGUpdate|Win32.Build.0 = PGUpdate|Win32
 		{7B2727B5-5A3F-40EE-A866-43A13CD31446}.PGUpdate|x64.ActiveCfg = PGUpdate|Win32
+		{7B2727B5-5A3F-40EE-A866-43A13CD31446}.PGUpdate|x64.Build.0 = PGUpdate|Win32
 		{7B2727B5-5A3F-40EE-A866-43A13CD31446}.Release|Win32.ActiveCfg = Release|Win32
 		{7B2727B5-5A3F-40EE-A866-43A13CD31446}.Release|Win32.Build.0 = Release|Win32
 		{7B2727B5-5A3F-40EE-A866-43A13CD31446}.Release|x64.ActiveCfg = Release|Win32
diff --git a/PCbuild/pywlauncher.vcxproj b/PCbuild/pywlauncher.vcxproj
index 0ada901932a..08e35a77411 100644
--- a/PCbuild/pywlauncher.vcxproj
+++ b/PCbuild/pywlauncher.vcxproj
@@ -61,6 +61,12 @@
     <WholeProgramOptimization>true</WholeProgramOptimization>
     <CharacterSet>Unicode</CharacterSet>
   </PropertyGroup>
+  <PropertyGroup Label="Configuration" Condition="'$(Configuration)|$(Platform)'=='PGInstrument|Win32'">
+    <CharacterSet>Unicode</CharacterSet>
+  </PropertyGroup>
+  <PropertyGroup Label="Configuration" Condition="'$(Configuration)|$(Platform)'=='PGUpdate|Win32'">
+    <CharacterSet>Unicode</CharacterSet>
+  </PropertyGroup>
   <Import Project="$(VCTargetsPath)\Microsoft.Cpp.props" />
   <ImportGroup Label="ExtensionSettings">
   </ImportGroup>
@@ -86,6 +92,32 @@
     <Import Project="release.props" />
     <Import Project="x64.props" />
   </ImportGroup>
+  <ImportGroup Condition="'$(Configuration)|$(Platform)'=='PGInstrument|Win32'" Label="PropertySheets">
+    <Import Project="$(UserRootDir)\Microsoft.Cpp.$(Platform).user.props" Condition="exists('$(UserRootDir)\Microsoft.Cpp.$(Platform).user.props')" Label="LocalAppDataPlatform" />
+    <Import Project="pyproject.props" />
+    <Import Project="release.props" />
+    <Import Project="pginstrument.props" />
+  </ImportGroup>
+  <ImportGroup Label="PropertySheets" Condition="'$(Configuration)|$(Platform)'=='PGInstrument|x64'">
+    <Import Project="$(UserRootDir)\Microsoft.Cpp.$(Platform).user.props" Condition="exists('$(UserRootDir)\Microsoft.Cpp.$(Platform).user.props')" Label="LocalAppDataPlatform" />
+    <Import Project="pyproject.props" />
+    <Import Project="release.props" />
+    <Import Project="x64.props" />
+    <Import Project="pginstrument.props" />
+  </ImportGroup>
+  <ImportGroup Label="PropertySheets" Condition="'$(Configuration)|$(Platform)'=='PGUpdate|Win32'">
+    <Import Project="$(UserRootDir)\Microsoft.Cpp.$(Platform).user.props" Condition="exists('$(UserRootDir)\Microsoft.Cpp.$(Platform).user.props')" Label="LocalAppDataPlatform" />
+    <Import Project="pyproject.props" />
+    <Import Project="release.props" />
+    <Import Project="pgupdate.props" />
+  </ImportGroup>
+  <ImportGroup Label="PropertySheets" Condition="'$(Configuration)|$(Platform)'=='PGUpdate|x64'">
+    <Import Project="$(UserRootDir)\Microsoft.Cpp.$(Platform).user.props" Condition="exists('$(UserRootDir)\Microsoft.Cpp.$(Platform).user.props')" Label="LocalAppDataPlatform" />
+    <Import Project="pyproject.props" />
+    <Import Project="release.props" />
+    <Import Project="x64.props" />
+    <Import Project="pgupdate.props" />
+  </ImportGroup>
   <PropertyGroup Label="UserMacros" />
   <PropertyGroup Condition="'$(Configuration)|$(Platform)'=='Debug|Win32'">
     <TargetName>pyw_d</TargetName>
@@ -171,21 +203,33 @@
     <Link>
       <AdditionalDependencies>version.lib;%(AdditionalDependencies)</AdditionalDependencies>
     </Link>
+    <ClCompile>
+      <PreprocessorDefinitions>_WINDOWS;NDEBUG;%(PreprocessorDefinitions)</PreprocessorDefinitions>
+    </ClCompile>
   </ItemDefinitionGroup>
   <ItemDefinitionGroup Condition="'$(Configuration)|$(Platform)'=='PGUpdate|Win32'">
     <Link>
       <AdditionalDependencies>version.lib;%(AdditionalDependencies)</AdditionalDependencies>
     </Link>
+    <ClCompile>
+      <PreprocessorDefinitions>_WINDOWS;NDEBUG;%(PreprocessorDefinitions)</PreprocessorDefinitions>
+    </ClCompile>
   </ItemDefinitionGroup>
   <ItemDefinitionGroup Condition="'$(Configuration)|$(Platform)'=='PGInstrument|x64'">
     <Link>
       <AdditionalDependencies>version.lib;%(AdditionalDependencies)</AdditionalDependencies>
     </Link>
+    <ClCompile>
+      <PreprocessorDefinitions>_WINDOWS;NDEBUG;_WIN64;_M_X64;%(PreprocessorDefinitions)</PreprocessorDefinitions>
+    </ClCompile>
   </ItemDefinitionGroup>
   <ItemDefinitionGroup Condition="'$(Configuration)|$(Platform)'=='PGUpdate|x64'">
     <Link>
       <AdditionalDependencies>version.lib;%(AdditionalDependencies)</AdditionalDependencies>
     </Link>
+    <ClCompile>
+      <PreprocessorDefinitions>_WINDOWS;NDEBUG;_WIN64;_M_X64;%(PreprocessorDefinitions)</PreprocessorDefinitions>
+    </ClCompile>
   </ItemDefinitionGroup>
   <ItemGroup>
     <ClCompile Include="..\PC\launcher.c" />
@@ -199,4 +243,4 @@
   <Import Project="$(VCTargetsPath)\Microsoft.Cpp.targets" />
   <ImportGroup Label="ExtensionTargets">
   </ImportGroup>
-</Project>
+</Project>
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