diff --git a/Misc/NEWS.d/next/Build/2021-11-16-14-44-06.bpo-45816.nbdmVK.rst b/Misc/NEWS.d/next/Build/2021-11-16-14-44-06.bpo-45816.nbdmVK.rst
new file mode 100644
index 00000000000..4a14c90bf01
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2021-11-16-14-44-06.bpo-45816.nbdmVK.rst
@@ -0,0 +1 @@
+Python now supports building with Visual Studio 2022 (MSVC v143, VS Version 17.0). Patch by Jeremiah Vivian.
\ No newline at end of file
diff --git a/PCbuild/pyproject.props b/PCbuild/pyproject.props
index bbcabb5cdb4..0eaeb6b1229 100644
--- a/PCbuild/pyproject.props
+++ b/PCbuild/pyproject.props
@@ -73,7 +73,7 @@
       <LinkTimeCodeGeneration Condition="$(SupportPGO) and $(Configuration) == 'PGInstrument'">PGInstrument</LinkTimeCodeGeneration>
       <LinkTimeCodeGeneration Condition="$(SupportPGO) and $(Configuration) == 'PGUpdate'">PGUpdate</LinkTimeCodeGeneration>
       <AdditionalDependencies>advapi32.lib;shell32.lib;ole32.lib;oleaut32.lib;%(AdditionalDependencies)</AdditionalDependencies>
-      <AdditionalOptions Condition="$(Configuration) != 'Debug'">/OPT:REF,NOICF %(AdditionalOptions)</AdditionalOptions>
+      <AdditionalOptions Condition="$(Configuration) != 'Debug'">/OPT:REF,NOICF /CGTHREADS:1 /PDBTHREADS:1 %(AdditionalOptions)</AdditionalOptions>
     </Link>
     <Lib>
       <LinkTimeCodeGeneration Condition="$(Configuration) == 'Release'">true</LinkTimeCodeGeneration>
diff --git a/PCbuild/python.props b/PCbuild/python.props
index c608fb9ee71..7b85ad1c94f 100644
--- a/PCbuild/python.props
+++ b/PCbuild/python.props
@@ -11,7 +11,7 @@
 
     We set BasePlatformToolset for ICC's benefit, it's otherwise ignored.
     -->
-    <BasePlatformToolset Condition="'$(BasePlatformToolset)' == '' and '$(VisualStudioVersion)' == '17.0'">v142</BasePlatformToolset>
+    <BasePlatformToolset Condition="'$(BasePlatformToolset)' == '' and '$(VisualStudioVersion)' == '17.0'">v143</BasePlatformToolset>
     <BasePlatformToolset Condition="'$(BasePlatformToolset)' == '' and '$(VisualStudioVersion)' == '16.0'">v142</BasePlatformToolset>
     <BasePlatformToolset Condition="'$(BasePlatformToolset)' == '' and ('$(MSBuildToolsVersion)' == '15.0' or '$(VisualStudioVersion)' == '15.0')">v141</BasePlatformToolset>
     <BasePlatformToolset Condition="'$(BasePlatformToolset)' == '' and '$(VCTargetsPath14)' != ''">v140</BasePlatformToolset>
diff --git a/PCbuild/pythoncore.vcxproj b/PCbuild/pythoncore.vcxproj
index b446e099556..119650a1eec 100644
--- a/PCbuild/pythoncore.vcxproj
+++ b/PCbuild/pythoncore.vcxproj
@@ -588,7 +588,7 @@
       </ClCompile>
     </ItemGroup>
   </Target>
-  <Target Name="_WarnAboutToolset" BeforeTargets="PrepareForBuild" Condition="$(PlatformToolset) != 'v140' and $(PlatformToolset) != 'v141' and $(PlatformToolset) != 'v142'">
+  <Target Name="_WarnAboutToolset" BeforeTargets="PrepareForBuild" Condition="$(PlatformToolset) != 'v140' and $(PlatformToolset) != 'v141' and $(PlatformToolset) != 'v142' and $(PlatformToolset) != 'v143'">
     <Warning Text="Toolset $(PlatformToolset) is not used for official builds. Your build may have errors or incompatibilities." />
   </Target>
   <Target Name="_WarnAboutZlib" BeforeTargets="PrepareForBuild" Condition="!$(IncludeExternals)">
diff --git a/Tools/msi/bundle/bootstrap/pythonba.vcxproj b/Tools/msi/bundle/bootstrap/pythonba.vcxproj
index ef71fe7da08..d90b5e3ff00 100644
--- a/Tools/msi/bundle/bootstrap/pythonba.vcxproj
+++ b/Tools/msi/bundle/bootstrap/pythonba.vcxproj
@@ -73,4 +73,4 @@
     <None Include="pythonba.def" />
   </ItemGroup>
   <Import Project="$(VCTargetsPath)\Microsoft.Cpp.targets" />
-</Project>
\ No newline at end of file
+</Project>