diff --git a/Doc/whatsnew/3.13.rst b/Doc/whatsnew/3.13.rst
index bbc1fecf496..b0a0d89c8d9 100644
--- a/Doc/whatsnew/3.13.rst
+++ b/Doc/whatsnew/3.13.rst
@@ -1075,6 +1075,11 @@ Porting to Python 3.13
   :c:func:`!Py_TOLOWER`.
   (Contributed by Victor Stinner in :gh:`108765`.)
 
+* If the :c:macro:`Py_LIMITED_API` macro is defined, :c:macro:`!Py_BUILD_CORE`,
+  :c:macro:`!Py_BUILD_CORE_BUILTIN` and :c:macro:`!Py_BUILD_CORE_MODULE` macros
+  are now undefined by ``<Python.h>``.
+  (Contributed by Victor Stinner in :gh:`85283`.)
+
 Deprecated
 ----------
 
diff --git a/Include/pyport.h b/Include/pyport.h
index 40d580a870f..d30fcd7f6cb 100644
--- a/Include/pyport.h
+++ b/Include/pyport.h
@@ -48,10 +48,6 @@
 #  define Py_BUILD_CORE
 #endif
 
-#if defined(Py_LIMITED_API) && defined(Py_BUILD_CORE)
-#  error "Py_LIMITED_API is not compatible with Py_BUILD_CORE"
-#endif
-
 
 /**************************************************************************
 Symbols and macros to supply platform-independent interfaces to basic
@@ -361,6 +357,15 @@ extern "C" {
 
 #include "exports.h"
 
+#ifdef Py_LIMITED_API
+   // The internal C API must not be used with the limited C API: make sure
+   // that Py_BUILD_CORE macro is not defined in this case. These 3 macros are
+   // used by exports.h, so only undefine them afterwards.
+#  undef Py_BUILD_CORE
+#  undef Py_BUILD_CORE_BUILTIN
+#  undef Py_BUILD_CORE_MODULE
+#endif
+
 /* limits.h constants that may be missing */
 
 #ifndef INT_MAX
diff --git a/Misc/NEWS.d/next/C API/2023-10-11-17-29-52.gh-issue-85283.OsqIBF.rst b/Misc/NEWS.d/next/C API/2023-10-11-17-29-52.gh-issue-85283.OsqIBF.rst
new file mode 100644
index 00000000000..c89a02985f4
--- /dev/null
+++ b/Misc/NEWS.d/next/C API/2023-10-11-17-29-52.gh-issue-85283.OsqIBF.rst	
@@ -0,0 +1,3 @@
+If the :c:macro:`Py_LIMITED_API` macro is defined, :c:macro:`!Py_BUILD_CORE`,
+:c:macro:`!Py_BUILD_CORE_BUILTIN` and :c:macro:`!Py_BUILD_CORE_MODULE` macros
+are now undefined by ``<Python.h>``. Patch by Victor Stinner.