diff --git a/Lib/test/test_generated_cases.py b/Lib/test/test_generated_cases.py
index 5b15838f077..cd3718b8061 100644
--- a/Lib/test/test_generated_cases.py
+++ b/Lib/test/test_generated_cases.py
@@ -450,7 +450,7 @@ class TestGeneratedCases(unittest.TestCase):
     """
         output = """
         TARGET(OP) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 4;
             INSTRUCTION_STATS(OP);
@@ -503,7 +503,7 @@ class TestGeneratedCases(unittest.TestCase):
             next_instr += 6;
             INSTRUCTION_STATS(OP);
             PREDICTED(OP);
-            _Py_CODEUNIT *this_instr = next_instr - 6;
+            _Py_CODEUNIT* const this_instr = next_instr - 6;
             (void)this_instr;
             _PyStackRef left;
             _PyStackRef right;
@@ -536,7 +536,7 @@ class TestGeneratedCases(unittest.TestCase):
         }
 
         TARGET(OP1) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(OP1);
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2024-10-07-23-33-18.gh-issue-125039.MKTyNI.rst b/Misc/NEWS.d/next/Core_and_Builtins/2024-10-07-23-33-18.gh-issue-125039.MKTyNI.rst
new file mode 100644
index 00000000000..93716c0b1c0
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2024-10-07-23-33-18.gh-issue-125039.MKTyNI.rst
@@ -0,0 +1 @@
+Make ``this_instr`` and ``prev_instr`` const in cases generator.
diff --git a/Python/generated_cases.c.h b/Python/generated_cases.c.h
index e1107caa197..c4de7bdeb4c 100644
--- a/Python/generated_cases.c.h
+++ b/Python/generated_cases.c.h
@@ -14,7 +14,7 @@
             next_instr += 2;
             INSTRUCTION_STATS(BINARY_OP);
             PREDICTED(BINARY_OP);
-            _Py_CODEUNIT *this_instr = next_instr - 2;
+            _Py_CODEUNIT* const this_instr = next_instr - 2;
             (void)this_instr;
             _PyStackRef lhs;
             _PyStackRef rhs;
@@ -422,7 +422,7 @@
             next_instr += 2;
             INSTRUCTION_STATS(BINARY_SUBSCR);
             PREDICTED(BINARY_SUBSCR);
-            _Py_CODEUNIT *this_instr = next_instr - 2;
+            _Py_CODEUNIT* const this_instr = next_instr - 2;
             (void)this_instr;
             _PyStackRef container;
             _PyStackRef sub;
@@ -858,7 +858,7 @@
             next_instr += 4;
             INSTRUCTION_STATS(CALL);
             PREDICTED(CALL);
-            _Py_CODEUNIT *this_instr = next_instr - 4;
+            _Py_CODEUNIT* const this_instr = next_instr - 4;
             (void)this_instr;
             _PyStackRef *callable;
             _PyStackRef *self_or_null;
@@ -1012,7 +1012,7 @@
         }
 
         TARGET(CALL_ALLOC_AND_ENTER_INIT) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 4;
             INSTRUCTION_STATS(CALL_ALLOC_AND_ENTER_INIT);
             static_assert(INLINE_CACHE_ENTRIES_CALL == 3, "incorrect cache size");
@@ -1107,7 +1107,7 @@
         }
 
         TARGET(CALL_BOUND_METHOD_EXACT_ARGS) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 4;
             INSTRUCTION_STATS(CALL_BOUND_METHOD_EXACT_ARGS);
             static_assert(INLINE_CACHE_ENTRIES_CALL == 3, "incorrect cache size");
@@ -1210,7 +1210,7 @@
         }
 
         TARGET(CALL_BOUND_METHOD_GENERAL) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 4;
             INSTRUCTION_STATS(CALL_BOUND_METHOD_GENERAL);
             static_assert(INLINE_CACHE_ENTRIES_CALL == 3, "incorrect cache size");
@@ -1625,7 +1625,7 @@
             next_instr += 1;
             INSTRUCTION_STATS(CALL_FUNCTION_EX);
             PREDICTED(CALL_FUNCTION_EX);
-            _Py_CODEUNIT *this_instr = next_instr - 1;
+            _Py_CODEUNIT* const this_instr = next_instr - 1;
             (void)this_instr;
             _PyStackRef func;
             _PyStackRef callargs;
@@ -1871,7 +1871,7 @@
             next_instr += 4;
             INSTRUCTION_STATS(CALL_KW);
             PREDICTED(CALL_KW);
-            _Py_CODEUNIT *this_instr = next_instr - 4;
+            _Py_CODEUNIT* const this_instr = next_instr - 4;
             (void)this_instr;
             _PyStackRef *callable;
             _PyStackRef *self_or_null;
@@ -2024,7 +2024,7 @@
         }
 
         TARGET(CALL_KW_BOUND_METHOD) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 4;
             INSTRUCTION_STATS(CALL_KW_BOUND_METHOD);
             static_assert(INLINE_CACHE_ENTRIES_CALL_KW == 3, "incorrect cache size");
@@ -2223,7 +2223,7 @@
         }
 
         TARGET(CALL_KW_PY) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 4;
             INSTRUCTION_STATS(CALL_KW_PY);
             static_assert(INLINE_CACHE_ENTRIES_CALL_KW == 3, "incorrect cache size");
@@ -2795,7 +2795,7 @@
         }
 
         TARGET(CALL_PY_EXACT_ARGS) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 4;
             INSTRUCTION_STATS(CALL_PY_EXACT_ARGS);
             static_assert(INLINE_CACHE_ENTRIES_CALL == 3, "incorrect cache size");
@@ -2876,7 +2876,7 @@
         }
 
         TARGET(CALL_PY_GENERAL) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 4;
             INSTRUCTION_STATS(CALL_PY_GENERAL);
             static_assert(INLINE_CACHE_ENTRIES_CALL == 3, "incorrect cache size");
@@ -3157,7 +3157,7 @@
         }
 
         TARGET(CLEANUP_THROW) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(CLEANUP_THROW);
@@ -3201,7 +3201,7 @@
             next_instr += 2;
             INSTRUCTION_STATS(COMPARE_OP);
             PREDICTED(COMPARE_OP);
-            _Py_CODEUNIT *this_instr = next_instr - 2;
+            _Py_CODEUNIT* const this_instr = next_instr - 2;
             (void)this_instr;
             _PyStackRef left;
             _PyStackRef right;
@@ -3381,7 +3381,7 @@
             next_instr += 2;
             INSTRUCTION_STATS(CONTAINS_OP);
             PREDICTED(CONTAINS_OP);
-            _Py_CODEUNIT *this_instr = next_instr - 2;
+            _Py_CODEUNIT* const this_instr = next_instr - 2;
             (void)this_instr;
             _PyStackRef left;
             _PyStackRef right;
@@ -3720,7 +3720,7 @@
         }
 
         TARGET(END_ASYNC_FOR) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(END_ASYNC_FOR);
@@ -3781,7 +3781,7 @@
         }
 
         TARGET(ENTER_EXECUTOR) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(ENTER_EXECUTOR);
@@ -3896,7 +3896,7 @@
             next_instr += 2;
             INSTRUCTION_STATS(FOR_ITER);
             PREDICTED(FOR_ITER);
-            _Py_CODEUNIT *this_instr = next_instr - 2;
+            _Py_CODEUNIT* const this_instr = next_instr - 2;
             (void)this_instr;
             _PyStackRef iter;
             _PyStackRef next;
@@ -4357,7 +4357,7 @@
         }
 
         TARGET(INSTRUMENTED_CALL) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 4;
             INSTRUCTION_STATS(INSTRUMENTED_CALL);
@@ -4530,7 +4530,7 @@
         }
 
         TARGET(INSTRUMENTED_CALL_KW) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 4;
             INSTRUCTION_STATS(INSTRUMENTED_CALL_KW);
@@ -4554,7 +4554,7 @@
         }
 
         TARGET(INSTRUMENTED_END_FOR) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(INSTRUMENTED_END_FOR);
@@ -4579,7 +4579,7 @@
         }
 
         TARGET(INSTRUMENTED_END_SEND) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(INSTRUMENTED_END_SEND);
@@ -4606,7 +4606,7 @@
         }
 
         TARGET(INSTRUMENTED_FOR_ITER) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(INSTRUMENTED_FOR_ITER);
@@ -4647,7 +4647,7 @@
         }
 
         TARGET(INSTRUMENTED_INSTRUCTION) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(INSTRUMENTED_INSTRUCTION);
@@ -4666,7 +4666,7 @@
         }
 
         TARGET(INSTRUMENTED_JUMP_BACKWARD) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(INSTRUMENTED_JUMP_BACKWARD);
@@ -4690,7 +4690,7 @@
         }
 
         TARGET(INSTRUMENTED_JUMP_FORWARD) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(INSTRUMENTED_JUMP_FORWARD);
@@ -4699,8 +4699,8 @@
         }
 
         TARGET(INSTRUMENTED_LINE) {
-            _Py_CODEUNIT *prev_instr = frame->instr_ptr;
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const prev_instr = frame->instr_ptr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(INSTRUMENTED_LINE);
@@ -4734,7 +4734,7 @@
         }
 
         TARGET(INSTRUMENTED_LOAD_SUPER_ATTR) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(INSTRUMENTED_LOAD_SUPER_ATTR);
@@ -4748,7 +4748,7 @@
         }
 
         TARGET(INSTRUMENTED_POP_JUMP_IF_FALSE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(INSTRUMENTED_POP_JUMP_IF_FALSE);
@@ -4765,7 +4765,7 @@
         }
 
         TARGET(INSTRUMENTED_POP_JUMP_IF_NONE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(INSTRUMENTED_POP_JUMP_IF_NONE);
@@ -4788,7 +4788,7 @@
         }
 
         TARGET(INSTRUMENTED_POP_JUMP_IF_NOT_NONE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(INSTRUMENTED_POP_JUMP_IF_NOT_NONE);
@@ -4811,7 +4811,7 @@
         }
 
         TARGET(INSTRUMENTED_POP_JUMP_IF_TRUE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(INSTRUMENTED_POP_JUMP_IF_TRUE);
@@ -4828,7 +4828,7 @@
         }
 
         TARGET(INSTRUMENTED_RESUME) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(INSTRUMENTED_RESUME);
@@ -4878,7 +4878,7 @@
         }
 
         TARGET(INSTRUMENTED_RETURN_CONST) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(INSTRUMENTED_RETURN_CONST);
@@ -4931,7 +4931,7 @@
         }
 
         TARGET(INSTRUMENTED_RETURN_VALUE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(INSTRUMENTED_RETURN_VALUE);
@@ -4976,7 +4976,7 @@
         }
 
         TARGET(INSTRUMENTED_YIELD_VALUE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(INSTRUMENTED_YIELD_VALUE);
@@ -5087,7 +5087,7 @@
         }
 
         TARGET(JUMP_BACKWARD) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(JUMP_BACKWARD);
@@ -5220,7 +5220,7 @@
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR);
             PREDICTED(LOAD_ATTR);
-            _Py_CODEUNIT *this_instr = next_instr - 10;
+            _Py_CODEUNIT* const this_instr = next_instr - 10;
             (void)this_instr;
             _PyStackRef owner;
             _PyStackRef attr;
@@ -5294,7 +5294,7 @@
         }
 
         TARGET(LOAD_ATTR_CLASS) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_CLASS);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5329,7 +5329,7 @@
         }
 
         TARGET(LOAD_ATTR_CLASS_WITH_METACLASS_CHECK) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_CLASS_WITH_METACLASS_CHECK);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5370,7 +5370,7 @@
         }
 
         TARGET(LOAD_ATTR_GETATTRIBUTE_OVERRIDDEN) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_GETATTRIBUTE_OVERRIDDEN);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5406,7 +5406,7 @@
         }
 
         TARGET(LOAD_ATTR_INSTANCE_VALUE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_INSTANCE_VALUE);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5451,7 +5451,7 @@
         }
 
         TARGET(LOAD_ATTR_METHOD_LAZY_DICT) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_METHOD_LAZY_DICT);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5494,7 +5494,7 @@
         }
 
         TARGET(LOAD_ATTR_METHOD_NO_DICT) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_METHOD_NO_DICT);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5530,7 +5530,7 @@
         }
 
         TARGET(LOAD_ATTR_METHOD_WITH_VALUES) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_METHOD_WITH_VALUES);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5578,7 +5578,7 @@
         }
 
         TARGET(LOAD_ATTR_MODULE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_MODULE);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5621,7 +5621,7 @@
         }
 
         TARGET(LOAD_ATTR_NONDESCRIPTOR_NO_DICT) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_NONDESCRIPTOR_NO_DICT);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5652,7 +5652,7 @@
         }
 
         TARGET(LOAD_ATTR_NONDESCRIPTOR_WITH_VALUES) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_NONDESCRIPTOR_WITH_VALUES);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5694,7 +5694,7 @@
         }
 
         TARGET(LOAD_ATTR_PROPERTY) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_PROPERTY);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5759,7 +5759,7 @@
         }
 
         TARGET(LOAD_ATTR_SLOT) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_SLOT);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -5796,7 +5796,7 @@
         }
 
         TARGET(LOAD_ATTR_WITH_HINT) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 10;
             INSTRUCTION_STATS(LOAD_ATTR_WITH_HINT);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_ATTR == 9, "incorrect cache size");
@@ -6101,7 +6101,7 @@
             next_instr += 5;
             INSTRUCTION_STATS(LOAD_GLOBAL);
             PREDICTED(LOAD_GLOBAL);
-            _Py_CODEUNIT *this_instr = next_instr - 5;
+            _Py_CODEUNIT* const this_instr = next_instr - 5;
             (void)this_instr;
             _PyStackRef *res;
             _PyStackRef null = PyStackRef_NULL;
@@ -6142,7 +6142,7 @@
         }
 
         TARGET(LOAD_GLOBAL_BUILTIN) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 5;
             INSTRUCTION_STATS(LOAD_GLOBAL_BUILTIN);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_GLOBAL == 4, "incorrect cache size");
@@ -6185,7 +6185,7 @@
         }
 
         TARGET(LOAD_GLOBAL_MODULE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 5;
             INSTRUCTION_STATS(LOAD_GLOBAL_MODULE);
             static_assert(INLINE_CACHE_ENTRIES_LOAD_GLOBAL == 4, "incorrect cache size");
@@ -6299,7 +6299,7 @@
             next_instr += 2;
             INSTRUCTION_STATS(LOAD_SUPER_ATTR);
             PREDICTED(LOAD_SUPER_ATTR);
-            _Py_CODEUNIT *this_instr = next_instr - 2;
+            _Py_CODEUNIT* const this_instr = next_instr - 2;
             (void)this_instr;
             _PyStackRef global_super_st;
             _PyStackRef class_st;
@@ -6654,7 +6654,7 @@
         }
 
         TARGET(POP_JUMP_IF_FALSE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(POP_JUMP_IF_FALSE);
@@ -6673,7 +6673,7 @@
         }
 
         TARGET(POP_JUMP_IF_NONE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(POP_JUMP_IF_NONE);
@@ -6708,7 +6708,7 @@
         }
 
         TARGET(POP_JUMP_IF_NOT_NONE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(POP_JUMP_IF_NOT_NONE);
@@ -6743,7 +6743,7 @@
         }
 
         TARGET(POP_JUMP_IF_TRUE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 2;
             INSTRUCTION_STATS(POP_JUMP_IF_TRUE);
@@ -6811,7 +6811,7 @@
         }
 
         TARGET(RAISE_VARARGS) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(RAISE_VARARGS);
@@ -6836,7 +6836,7 @@
         }
 
         TARGET(RERAISE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             (void)this_instr;
             next_instr += 1;
             INSTRUCTION_STATS(RERAISE);
@@ -6886,7 +6886,7 @@
             next_instr += 1;
             INSTRUCTION_STATS(RESUME);
             PREDICTED(RESUME);
-            _Py_CODEUNIT *this_instr = next_instr - 1;
+            _Py_CODEUNIT* const this_instr = next_instr - 1;
             (void)this_instr;
             // _MAYBE_INSTRUMENT
             {
@@ -7049,7 +7049,7 @@
             next_instr += 2;
             INSTRUCTION_STATS(SEND);
             PREDICTED(SEND);
-            _Py_CODEUNIT *this_instr = next_instr - 2;
+            _Py_CODEUNIT* const this_instr = next_instr - 2;
             (void)this_instr;
             _PyStackRef receiver;
             _PyStackRef v;
@@ -7288,7 +7288,7 @@
             next_instr += 5;
             INSTRUCTION_STATS(STORE_ATTR);
             PREDICTED(STORE_ATTR);
-            _Py_CODEUNIT *this_instr = next_instr - 5;
+            _Py_CODEUNIT* const this_instr = next_instr - 5;
             (void)this_instr;
             _PyStackRef owner;
             _PyStackRef v;
@@ -7329,7 +7329,7 @@
         }
 
         TARGET(STORE_ATTR_INSTANCE_VALUE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 5;
             INSTRUCTION_STATS(STORE_ATTR_INSTANCE_VALUE);
             static_assert(INLINE_CACHE_ENTRIES_STORE_ATTR == 4, "incorrect cache size");
@@ -7378,7 +7378,7 @@
         }
 
         TARGET(STORE_ATTR_SLOT) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 5;
             INSTRUCTION_STATS(STORE_ATTR_SLOT);
             static_assert(INLINE_CACHE_ENTRIES_STORE_ATTR == 4, "incorrect cache size");
@@ -7411,7 +7411,7 @@
         }
 
         TARGET(STORE_ATTR_WITH_HINT) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 5;
             INSTRUCTION_STATS(STORE_ATTR_WITH_HINT);
             static_assert(INLINE_CACHE_ENTRIES_STORE_ATTR == 4, "incorrect cache size");
@@ -7625,7 +7625,7 @@
             next_instr += 2;
             INSTRUCTION_STATS(STORE_SUBSCR);
             PREDICTED(STORE_SUBSCR);
-            _Py_CODEUNIT *this_instr = next_instr - 2;
+            _Py_CODEUNIT* const this_instr = next_instr - 2;
             (void)this_instr;
             _PyStackRef container;
             _PyStackRef sub;
@@ -7748,7 +7748,7 @@
             next_instr += 4;
             INSTRUCTION_STATS(TO_BOOL);
             PREDICTED(TO_BOOL);
-            _Py_CODEUNIT *this_instr = next_instr - 4;
+            _Py_CODEUNIT* const this_instr = next_instr - 4;
             (void)this_instr;
             _PyStackRef value;
             _PyStackRef res;
@@ -7784,7 +7784,7 @@
         }
 
         TARGET(TO_BOOL_ALWAYS_TRUE) {
-            _Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;
+            _Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;
             next_instr += 4;
             INSTRUCTION_STATS(TO_BOOL_ALWAYS_TRUE);
             static_assert(INLINE_CACHE_ENTRIES_TO_BOOL == 3, "incorrect cache size");
@@ -7984,7 +7984,7 @@
             next_instr += 2;
             INSTRUCTION_STATS(UNPACK_SEQUENCE);
             PREDICTED(UNPACK_SEQUENCE);
-            _Py_CODEUNIT *this_instr = next_instr - 2;
+            _Py_CODEUNIT* const this_instr = next_instr - 2;
             (void)this_instr;
             _PyStackRef seq;
             _PyStackRef *output;
diff --git a/Tools/cases_generator/tier1_generator.py b/Tools/cases_generator/tier1_generator.py
index 1b116a578c5..8dadc5736c8 100644
--- a/Tools/cases_generator/tier1_generator.py
+++ b/Tools/cases_generator/tier1_generator.py
@@ -150,9 +150,9 @@ def generate_tier1(
         out.emit(f"TARGET({name}) {{\n")
         unused_guard = "(void)this_instr;\n" if inst.family is None else ""
         if inst.properties.needs_prev:
-            out.emit(f"_Py_CODEUNIT *prev_instr = frame->instr_ptr;\n")
+            out.emit(f"_Py_CODEUNIT* const prev_instr = frame->instr_ptr;\n")
         if needs_this and not inst.is_target:
-            out.emit(f"_Py_CODEUNIT *this_instr = frame->instr_ptr = next_instr;\n")
+            out.emit(f"_Py_CODEUNIT* const this_instr = frame->instr_ptr = next_instr;\n")
             out.emit(unused_guard)
         else:
             out.emit(f"frame->instr_ptr = next_instr;\n")
@@ -161,7 +161,7 @@ def generate_tier1(
         if inst.is_target:
             out.emit(f"PREDICTED({name});\n")
             if needs_this:
-                out.emit(f"_Py_CODEUNIT *this_instr = next_instr - {inst.size};\n")
+                out.emit(f"_Py_CODEUNIT* const this_instr = next_instr - {inst.size};\n")
                 out.emit(unused_guard)
         if inst.family is not None:
             out.emit(