diff --git a/Misc/NEWS.d/next/Windows/2022-08-04-18-47-54.gh-issue-95656.VJ1d13.rst b/Misc/NEWS.d/next/Windows/2022-08-04-18-47-54.gh-issue-95656.VJ1d13.rst
new file mode 100644
index 00000000000..77fea4c33f7
--- /dev/null
+++ b/Misc/NEWS.d/next/Windows/2022-08-04-18-47-54.gh-issue-95656.VJ1d13.rst
@@ -0,0 +1,2 @@
+Enable the :meth:`~sqlite3.Connection.enable_load_extension` :mod:`sqlite3`
+API.
diff --git a/PCbuild/_sqlite3.vcxproj b/PCbuild/_sqlite3.vcxproj
index 804aa07367a..57c7413671e 100644
--- a/PCbuild/_sqlite3.vcxproj
+++ b/PCbuild/_sqlite3.vcxproj
@@ -94,7 +94,7 @@
   <ItemDefinitionGroup>
     <ClCompile>
       <AdditionalIncludeDirectories>$(sqlite3Dir);%(AdditionalIncludeDirectories)</AdditionalIncludeDirectories>
-      <PreprocessorDefinitions>PY_SQLITE_HAVE_SERIALIZE;%(PreprocessorDefinitions)</PreprocessorDefinitions>
+      <PreprocessorDefinitions>PY_SQLITE_HAVE_SERIALIZE;PY_SQLITE_ENABLE_LOAD_EXTENSION;%(PreprocessorDefinitions)</PreprocessorDefinitions>
     </ClCompile>
   </ItemDefinitionGroup>
   <ItemGroup>