diff --git a/Lib/sysconfig.py b/Lib/sysconfig.py
index 95b48f6429d..86a9c466103 100644
--- a/Lib/sysconfig.py
+++ b/Lib/sysconfig.py
@@ -37,10 +37,10 @@ _INSTALL_SCHEMES = {
         'data': '{base}',
         },
     'posix_home': {
-        'stdlib': '{installed_base}/lib/python',
-        'platstdlib': '{base}/lib/python',
+        'stdlib': '{installed_base}/{platlibdir}/python',
+        'platstdlib': '{base}/{platlibdir}/python',
         'purelib': '{base}/lib/python',
-        'platlib': '{base}/lib/python',
+        'platlib': '{base}/{platlibdir}/python',
         'include': '{installed_base}/include/python',
         'platinclude': '{installed_base}/include/python',
         'scripts': '{base}/bin',
diff --git a/Misc/NEWS.d/next/Library/2021-08-28-14-52-27.bpo-45035.O9mNam.rst b/Misc/NEWS.d/next/Library/2021-08-28-14-52-27.bpo-45035.O9mNam.rst
new file mode 100644
index 00000000000..b26c51ac17e
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2021-08-28-14-52-27.bpo-45035.O9mNam.rst
@@ -0,0 +1,2 @@
+Fix the ``posix_home`` scheme in :mod:`sysconfig` to depend on
+:data:`sys.platlibdir`.