diff --git a/Lib/site.py b/Lib/site.py
index b11cd48e69e..69670d9d7f2 100644
--- a/Lib/site.py
+++ b/Lib/site.py
@@ -266,8 +266,8 @@ def _getuserbase():
     if env_base:
         return env_base
 
-    # VxWorks has no home directories
-    if sys.platform == "vxworks":
+    # Emscripten, VxWorks, and WASI have no home directories
+    if sys.platform in {"emscripten", "vxworks", "wasi"}:
         return None
 
     def joinuser(*args):
diff --git a/Lib/sysconfig.py b/Lib/sysconfig.py
index e21b7303fec..bf926cf7680 100644
--- a/Lib/sysconfig.py
+++ b/Lib/sysconfig.py
@@ -111,8 +111,8 @@ def _getuserbase():
     if env_base:
         return env_base
 
-    # VxWorks has no home directories
-    if sys.platform == "vxworks":
+    # Emscripten, VxWorks, and WASI have no home directories
+    if sys.platform in {"emscripten", "vxworks", "wasi"}:
         return None
 
     def joinuser(*args):
diff --git a/Misc/NEWS.d/next/Library/2022-06-09-10-12-55.gh-issue-90473.683m_C.rst b/Misc/NEWS.d/next/Library/2022-06-09-10-12-55.gh-issue-90473.683m_C.rst
new file mode 100644
index 00000000000..b053a8e9a08
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-06-09-10-12-55.gh-issue-90473.683m_C.rst
@@ -0,0 +1,2 @@
+Emscripten and WASI have no home directory and cannot provide :pep:`370`
+user site directory.